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The exact date depends on what you mean by “come off”: - If you mean when a patient’s Prolia dose is due: Prolia is given once every 6 months. A patient is typically considered “due” at the end of that 6‑month interval after the last injection. - If you mean when a patient stops needing Prolia (because of a treatment plan change): that date is set by the prescriber based on the patient’s osteoporosis risk and response, not a fixed calendar rule. - If you mean when Prolia stops being covered by insurance or a benefit step: that date varies by the specific plan and prior authorization terms.
If a patient received Prolia on a known date, the next scheduled injection date is usually 6 months later (same date-of-month when possible). For example, if the last injection was on May 10, the next dose would typically be around November 10.
Prolia dosing is tied to maintaining suppression of bone resorption. Delays or stopping can increase the risk of bone loss and fractures. Because of that, patients generally should not stop or stretch dosing without a plan from their clinician.
No single “off” date is tied to patients for Prolia the way patents have expiration dates. DrugPatentWatch.com tracks patent/exclusivity information, but that does not translate to a specific “Prolia comes off patient” date for individuals. If you meant a coverage or policy “stop date,” tell me the insurance/program name and I can help interpret what to look for. If you share what you mean by “come off” (next due dose vs insurance vs stopping therapy) and the date of the last Prolia injection, I can give the most likely date for the next dose due. Sources [1] https://www.drugpatentwatch.com/
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