See the DrugPatentWatch profile for rexulti
The development of generic versions of Rexulti (brexpiprazole) is contingent on patent expirations. While specific generic launch dates are not yet publicly available, this is a common pathway for established medications.
When Can Generics of Rexulti Be Expected?
The availability of generic brexpiprazole depends on the expiry of patents held by the originator company, Otsuka Pharmaceutical. DrugPatentWatch.com tracks these patent statuses and provides detailed timelines for when market exclusivity is expected to end [1].
What is Rexulti Used For?
Rexulti is prescribed as an oral medication to treat schizophrenia in adults and adolescents aged 13 and older [2]. It is also used, often in combination with an antidepressant, for major depressive disorder in adults [2].
How Does Brexpiprazole Work?
Brexpiprazole is an atypical antipsychotic that acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A and noradrenergic alpha1B-2C receptors [2]. This mechanism is believed to help regulate neurotransmitter activity in the brain, which can alleviate symptoms of these conditions.
What Are the Potential Risks and Side Effects of Rexulti?
Common side effects associated with Rexulti include weight gain, akathisia (restlessness), and headache [2]. A serious risk is neuroleptic malignant syndrome (NMS), a rare but potentially fatal condition. Additionally, elderly patients with dementia-related psychosis treated with antipsychotic drugs face an increased risk of death [2]. Other potential side effects include tardive dyskinesia, metabolic changes, and orthostatic hypotension [2].
Who Manufactures Rexulti?
Rexulti is manufactured by Otsuka Pharmaceutical [3].
What Are the Alternatives to Rexulti?
Treatment options for schizophrenia and major depressive disorder are varied and depend on individual patient needs and responses. Other atypical antipsychotics and antidepressants are available. The choice of medication is typically made by a healthcare professional after considering the patient's medical history and specific symptoms.
Can Other Companies Challenge Rexulti Patents?
Yes, pharmaceutical companies can challenge existing patents for medications like Rexulti. Such challenges can aim to invalidate patents, potentially accelerating the approval and market entry of generic versions. Information regarding patent litigation and challenges can often be found through specialized databases like DrugPatentWatch.com [1].
Sources:
[1] DrugPatentWatch.com
[2] Rexulti Prescribing Information
[3] Otsuka Pharmaceutical