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Keytruda’s first FDA approval (in 2014) was for unresectable or metastatic melanoma that had progressed after treatment with ipilimumab (Yervoy) and, if it was BRAF V600 mutation–positive, a BRAF inhibitor [1].
No. That first approval was specifically for the melanoma indication described above. Keytruda was later approved for additional cancers as new clinical data were reviewed by the FDA [1].
The initial FDA approval for Keytruda was granted in 2014 [1]. Sources: [1] https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-c-der?searchapifulltext=Keytruda%20unresectable%20metastatic%20melanoma%20ipilimumab%20BRAF%20inhibitor
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