Does Trulicity Need Refrigeration at All Times?
No, Trulicity (dulaglutide) pens do not require refrigeration at all times. Unopened pens must be stored in the refrigerator at 36°F to 46°F (2°C to 8°C), but they can be kept at room temperature up to 86°F (30°C) for up to 21 days without losing potency.[1][2]
What Happens After First Use?
Once opened or used for the first time, keep the pen at room temperature below 86°F (30°C) for up to 21 days. Do not return it to the fridge after the first use, as temperature swings can affect stability. Discard after 21 days or if expired.[1][2]
Can It Handle Room Temperature During Travel or Daily Use?
Yes, Trulicity tolerates short-term room temperature exposure. Unopened pens can stay out for up to 21 days total, making it suitable for travel without cooling packs unless temperatures exceed 86°F. Avoid direct sunlight, freezing, or heat sources like cars.[1][3]
Official Storage Guidelines from the Manufacturer
Eli Lilly's prescribing information specifies:
- Refrigerate unused pens.
- Allow pens to reach room temperature before injecting (about 30 minutes).
- Do not use if frozen, discolored, or past expiration.
These rules apply to all doses (0.75 mg to 4.5 mg).[1][2]
What If It Gets Too Hot or Frozen by Mistake?
If exposed to over 86°F for more than brief periods or frozen, discard the pen—do not use it. Heat degrades the protein-based drug, while freezing can cause permanent damage. Patients report no issues with standard carry-on travel if kept in shade.[1][3]
Sources
[1]: Trulicity Prescribing Information (Eli Lilly)
[2]: FDA Label for Trulicity
[3]: Drugs.com Storage Guide