Can Entresto (sacubitril/valsartan) cause tiredness or fatigue?
Yes. Fatigue (feeling tired or weak) is a known possible side effect of Entresto. Clinical trial and prescribing-information data for Entresto include fatigue among adverse reactions that can occur in people taking the drug [1].
What other symptoms might be confused with “tiredness”?
Some effects that people describe as tiredness can overlap with:
- Low blood pressure (dizziness, lightheadedness, weakness), which can make you feel drained.
- Worsening heart failure symptoms or reduced exercise tolerance (which should be assessed promptly).
- General side effects reported with heart-failure medicines.
If you feel unusually weak, dizzy, or faint, it is important to contact your clinician because Entresto can lower blood pressure [1].
When should you call a doctor about feeling tired on Entresto?
Get medical advice soon if fatigue is:
- New, worsening, or severe
- Paired with dizziness, fainting, unusually low blood pressure, shortness of breath, or swelling
These can signal problems such as low blood pressure or changes in your heart-failure status, and your dose may need adjustment [1].
Does tiredness mean Entresto is “not working”?
Not necessarily. Fatigue can happen even when the medication is beneficial. What matters is the pattern and severity of your symptoms, your blood pressure, and how you are feeling overall. Clinicians often adjust dose or address other contributing factors if side effects become limiting [1].
Sources
- Drug label information for Entresto (sacubitril/valsartan) as summarized on DrugPatentWatch.com: https://www.drugpatentwatch.com/