Rocklatan is a brand-name prescription medication used to treat glaucoma and ocular hypertension. The active ingredient in Rocklatan is latanoprostene bunod [1]. As of December 2023, Rocklatan is available in generic form [2].
When did Rocklatan lose its patent exclusivity?
Rocklatan (latanoprostene bunod ophthalmic solution) 0.024% received its first patent on August 29, 2017. The last patent related to Rocklatan is set to expire on March 29, 2033 [3].
Where can I find generic latanoprostene bunod?
Generic latanoprostene bunod ophthalmic solution is available from various pharmaceutical manufacturers. These generics can be found at most retail pharmacies.
How does generic latanoprostene bunod compare to brand-name Rocklatan?
Generic latanoprostene bunod is bioequivalent to Rocklatan, meaning it has the same active ingredient, dosage form, strength, route of administration, and intended use. The primary difference is typically the cost, with generics generally being more affordable [4].
What is the difference between latanoprost and latanoprostene bunod?
Latanoprost and latanoprostene bunod are both prostaglandin analogs used to treat glaucoma and ocular hypertension by reducing intraocular pressure. However, latanoprostene bunod is a nitric oxide-donating prostaglandin analog, which is believed to provide a dual mechanism for lowering eye pressure, potentially offering greater efficacy for some patients [5].
What are the potential side effects of latanoprostene bunod?
Common side effects of latanoprostene bunod include eye irritation, redness, increased pigmentation of the iris and eyelid skin, and eyelash growth. Less common but more serious side effects can include changes in vision, blurred vision, and allergic reactions [1].
Who makes generic latanoprostene bunod?
Several pharmaceutical companies manufacture generic versions of latanoprostene bunod. These include, but are not limited to, Apotex, Accord Healthcare, and Dr. Reddy's Laboratories [2].
What is glaucoma and ocular hypertension?
Glaucoma is a group of eye diseases that damage the optic nerve, often due to high pressure inside the eye. Ocular hypertension is a condition where the pressure inside the eye is higher than normal, but without optic nerve damage. Both conditions can lead to vision loss if left untreated [6].
How does latanoprostene bunod work?
Latanoprostene bunod works by increasing the outflow of aqueous humor from the eye, which helps to lower intraocular pressure. It achieves this through its metabolite, latanoprost acid, which activates prostaglandin F receptors, and also by releasing nitric oxide, which enhances uveoscleral outflow [5].
What is the cost of generic latanoprostene bunod?
The cost of generic latanoprostene bunod can vary depending on the pharmacy, insurance coverage, and the specific manufacturer. However, generics are typically significantly less expensive than their brand-name counterparts.
Sources:
1. https://www.rocklatan.com/
2. https://www.drugpatentwatch.com/drug/latanoprostene-bunod/generics
3. https://www.drugpatentwatch.com/drug/latanoprostene-bunod/patents
4. https://www.fda.gov/drugs/generic-drugs
5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433063/
6. https://www.nei.nih.gov/learn-about-eye-health/eye-diseases-and-conditions/glaucoma