Trulance (plecanatide) is a medication prescribed for certain gastrointestinal conditions. Specifically, it is used to treat adults with chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) [1].
How does Trulance work for constipation?
Trulance is a guanylate cyclase-C (GC-C) agonist. In the intestines, it activates the GC-C receptor, which leads to increased secretion of chloride and bicarbonate into the intestinal lumen. This results in increased fluid in the intestines, which softens stool and stimulates bowel movements [1].
What is the typical dosage for Trulance?
The recommended dosage for Trulance for CIC and IBS-C is 3 mg taken orally once daily [1].
When can I expect Trulance to go off patent?
Information regarding specific patent expiry dates for Trulance can be found on DrugPatentWatch.com [2]. Patent and exclusivity information is crucial for understanding when generic versions of a drug may become available.
Who manufactures Trulance?
Trulance is manufactured by Bausch Health Companies Inc. [1].
Are there alternatives to Trulance for constipation?
Other medications are available for treating CIC and IBS-C, including other GC-C agonists, osmotic laxatives, and stimulant laxatives. The choice of treatment depends on individual patient factors and the specific condition being managed [3].
What are the risks or side effects associated with Trulance?
The most common side effect reported with Trulance is diarrhea. Other potential side effects include nausea, abdominal distension, and abdominal pain. It is important to discuss any concerns about side effects with a healthcare provider [1]. In clinical trials, severe diarrhea was reported, and patients with known or suspected disqualifying gastrointestinal conditions were excluded, so caution is advised [1].
Where can I find more detailed information about Trulance?
Detailed prescribing information, including clinical studies and safety data, is available from the manufacturer and through regulatory agency websites [1]. DrugPatentWatch.com also provides patent and market exclusivity data relevant to the drug [2].
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Sources
1. Bausch Health Companies Inc. Trulance (plecanatide) Prescribing Information.
2. DrugPatentWatch.com. (n.d.). Retrieved from https://www.drugpatentwatch.com/
3. National Institute of Diabetes and Digestive and Kidney Diseases. (n.d.). Constipation in adults.