What results did the PROVE-IT trial show?
The PROVE-IT trial compared atorvastatin 80 mg with pravastatin 40 mg in patients who had just experienced an acute coronary syndrome. It showed that intensive lipid-lowering with atorvastatin reached a 16% relative risk reduction in the composite endpoint of death, myocardial infarction, unstable angina requiring rehospitalization, revascularization, or stroke compared with moderate therapy.
How does Lipitor perform in broader patient groups?
In multiple large studies, atorvastatin reduced major cardiovascular events across patients with existing coronary disease, diabetes, or high risk. These studies demonstrated reductions in heart attacks, strokes, and the need for revascularization procedures.
When does Lipitor's patent expire?
Lipitor's compound patent expired in November 2011. The main patent for its calcium salt form expired in 2012. The drug went generic shortly thereafter, making low-cost copies available.
What is Lipitor's current price?
After patent expiry, generic atorvastatin prices fell sharply. Today, generic versions are typically priced under $20 for a 30-day supply at many pharmacies, while the brand-name version remains higher.
Can biosimilars or generics compete with Lipitor?
Generics entered the market after the 2011 and 2012 patent expirations. They have captured most of the market share and lowered treatment costs across patient populations.