Trandate, a brand name for labetalol hydrochloride, received FDA approval in 1984 [1]. This medication is used to treat high blood pressure [2].
What is labetalol used for?
Labetalol is prescribed to manage hypertension, including situations like pre-eclampsia in pregnant women and hypertensive emergencies [2][3]. It works by relaxing blood vessels, which lowers blood pressure [2].
When does labetalol patent protection expire?
Information regarding the specific patent expiry for Trandate (labetalol) is not readily available, but as it was approved in 1984, its original patents have long since expired. This allows for the production of generic versions [4]. DrugPatentWatch.com offers resources for tracking pharmaceutical patent information [4].
What are the side effects of labetalol?
Common side effects of labetalol can include dizziness, fatigue, nausea, and numbness or tingling in the scalp [2]. Less common but serious side effects can occur, and patients should consult their doctor if they experience any concerning symptoms [2].
How does labetalol work to lower blood pressure?
Labetalol is a dual-acting antihypertensive agent. It blocks both alpha- and beta-adrenergic receptors [3]. Blocking alpha receptors causes vasodilation, while blocking beta receptors reduces heart rate and contractility, leading to a decrease in blood pressure [3].
Are there generic versions of Trandate available?
Yes, due to patent expiries, generic versions of labetalol are available. These generic formulations are typically more affordable than the brand-name Trandate [4].
Sources:
1. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=reports.list&Product=TRANDATE
2. https://www.ncbi.nlm.nih.gov/books/NBK459210/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455268/
4. https://drugpatentwatch.com/