See the DrugPatentWatch profile for zepbound
Recommended Starting Dose
Zepbound (tirzepatide) starts at 2.5 mg injected subcutaneously once weekly for weight loss in adults with obesity or overweight with weight-related conditions. This initial dose lasts for 4 weeks before titration.[1]
How Dosing Progresses
After 4 weeks on 2.5 mg, the dose increases to 5 mg weekly. Further increases occur every 4 weeks (to 7.5 mg, then 10 mg, 12.5 mg, and up to a maximum of 15 mg weekly) based on tolerance and response. Titration minimizes side effects like nausea.[1][2]
Who It's For and Administration Tips
Approved for chronic weight management alongside diet and exercise. Use a single-dose pen; inject into abdomen, thigh, or upper arm, rotating sites. Store refrigerated; can be unrefrigerated for up to 21 days.[1]
Common Side Effects at Starting Dose
Nausea, diarrhea, vomiting, constipation, and stomach pain are frequent early on, often improving with time or slower titration. Start with the lowest dose to reduce gastrointestinal issues.[1][2]
Cost and Access
A 4-week supply of 2.5 mg pens costs around $1,000-$1,300 without insurance. Savings cards from Eli Lilly can lower it to $25/month for eligible patients. No generic or patent expiry soon—key patents extend to 2036.1
[1]: Zepbound Prescribing Information, Eli Lilly (https://pi.lilly.com/us/zepbound-uspi.pdf)
[2]: FDA Approval Label for Tirzepatide (https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/217806s000lbl.pdf)