How many days of sivextro are needed for a skin infection?

Recommended Dosage Duration for Sivextro in Skin Infections

Sivextro (tedizolid phosphate) treats acute bacterial skin and skin structure infections (ABSSSI) in adults and children aged 12+ weighing at least 40 kg. The standard regimen is 200 mg taken orally or by IV infusion once daily for 6 days.[1][2]

Patients complete the full 6-day course, even if symptoms improve earlier, to clear the infection fully. For pediatric patients under 40 kg, dosing adjusts by weight (4 mg/kg once daily, max 200 mg), but duration remains 6 days.[2]

How Sivextro Differs from Vancomycin for Skin Infections

Unlike vancomycin, which often requires 7-14 days of twice-daily IV dosing for ABSSSI, Sivextro's shorter 6-day once-daily schedule improves patient convenience and adherence. Both target gram-positive bacteria like MRSA, but Sivextro has better oral bioavailability.[1][3]

What If the Infection Doesn't Respond After 6 Days?

Consult a doctor if symptoms persist or worsen after completing the course. Extended treatment beyond 6 days isn't standard and risks side effects like nausea, diarrhea, or rare liver issues. Culture tests guide any changes.[2][4]

Who Should Avoid or Adjust Sivextro Dosing?

Avoid in patients with hypersensitivity to tedizolid. No dose adjustment for mild-moderate kidney or liver impairment, but monitor closely in severe cases. It's not approved for kids under 12 or non-ABSSSI infections.[1][2]

[1]: Sivextro Prescribing Information (FDA)
[2]: Drugs.com - Sivextro Dosage
[3]: IDSA Guidelines for Skin Infections
[4]: Medscape - Tedizolid Dosing