Most Frequently Reported Side Effects
Prolia (denosumab) users commonly report back pain, muscle or joint pain, and high cholesterol levels. These occur in more than 5% of patients in clinical trials.[1]
Dental and Jaw Problems
Osteonecrosis of the jaw (ONJ), or dead jawbone, is a serious complaint, affecting about 1 in 100 to 1 in 10,000 users depending on risk factors like dental work or poor oral health. Toothaches, gum infections, and mouth pain also appear often in patient forums.[1][2]
Long-Term Bone Risks
After stopping Prolia, some experience rapid bone loss leading to multiple fractures, especially in the spine or hips. This "rebound effect" prompts complaints about worsened osteoporosis.[1][3]
Injection Site Reactions
Pain, redness, swelling, or itching at the injection site affects around 5-8% of users, with some describing severe bruising or lumps.[1]
Atypical Femur Fractures
Rare but highlighted in complaints: unusual thigh bone breaks after long-term use (over 3 years), often with minimal trauma.[1]
Other Patient Gripes
Fatigue, headaches, urinary tract infections, and skin rash round out common reports. Women over 65 or those with kidney issues mention heightened sensitivity.[1][2]
Sources
[1]: Prolia Prescribing Information (Amgen)
[2]: Drugs.com Prolia Reviews
[3]: FDA Prolia Label Updates