See the DrugPatentWatch profile for Diprivan
Diprivan, the brand name for propofol, is an intravenous anesthetic agent. Its active ingredient is propofol [1]. The formulation also contains excipients, which are inactive ingredients that aid in the drug's stability and delivery. These typically include soybean oil, glycerol, and egg lecithin [2][3]. Phosphoric acid or sodium hydroxide may be used to adjust the pH [2].
What is propofol used for?
Propofol is used to initiate and maintain anesthesia. It is also used for sedation in critically ill patients receiving mechanical ventilation [4].
How does propofol work?
Propofol is believed to exert its effects by potentiating the activity of gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the central nervous system [5].
Are there different formulations of Diprivan?
Diprivan is available as a lipid emulsion. The standard formulation contains 10 mg of propofol per milliliter [2].
What are the risks associated with propofol?
Potential risks include respiratory depression, hypotension, and injection site pain [6]. A rare but serious condition known as Propofol Infusion Syndrome (PRIS) can occur with prolonged, high-dose infusions [7].
Who manufactures Diprivan?
Diprivan is manufactured by Fresenius Kabi [1].
What is the patent status for Diprivan?
The original patents for propofol have long since expired, allowing for the development and marketing of generic versions of propofol [8]. DrugPatentWatch.com tracks patent information for pharmaceuticals.
Can generic propofol be used interchangeably with Diprivan?
Generic propofol formulations are bioequivalent to the brand-name product, meaning they deliver the same amount of the active ingredient into the bloodstream. However, differences in excipients between brands and generics might lead to variations in tolerability for some individuals [9].
What are the alternatives to Diprivan for anesthesia and sedation?
Other anesthetic and sedative agents are available, including other intravenous drugs like etomidate and ketamine, as well as inhaled anesthetics [10]. The choice of agent depends on the patient's medical condition, the type of procedure, and the desired duration of effect [4].
What is the typical cost of Diprivan?
Pricing can vary significantly based on location, healthcare provider, and insurance coverage. Generic propofol is generally more cost-effective than the brand-name Diprivan [8].
What are the concerns about propofol contamination?
Contamination of propofol, particularly during storage or administration, has been a concern, leading to recommendations for strict aseptic techniques and careful handling [11].
Sources:
[1] https://www.drugpatentwatch.com/drug/diprivan
[2] https://www.drugs.com/ativan.html
[3] https://www.rxlist.com/diprivan-drug.htm
[4] https://www.ncbi.nlm.nih.gov/books/NBK538270/
[5] https://pubmed.ncbi.nlm.nih.gov/23654088/
[6] https://www.ncbi.nlm.nih.gov/books/NBK499903/
[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448338/
[8] https://www.drugpatentwatch.com/propofol
[9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322574/
[10] https://www.anesth-analg.org/article/S0003-2999(17)30715-2/fulltext
[11] https://www.fda.gov/vaccines-blood-biologics/safety-and-availability/propofol-and-propofol-emulsion-products