Propofol is an anesthetic medication used for sedation and induction and maintenance of anesthesia. Its cost has fluctuated over time, influenced by manufacturing, demand, and market dynamics.
How much does Propofol cost currently?
The current cost of Propofol varies depending on the manufacturer, formulation, and quantity purchased. For instance, a 10-bag case of Diprivan (propofol injectable emulsion) 1% (10 mg/mL) can range from approximately $200 to $300 for a 10 mL vial, and larger volumes like 50 mL vials might cost around $500 to $800 per case. Generic versions are also available and typically cost less than branded products like Diprivan [1].
What factors influence Propofol pricing?
Propofol pricing is affected by several factors. These include the cost of raw materials, manufacturing processes, packaging, distribution, and the competitive landscape of generic versus brand-name products [1]. Shortages, often driven by manufacturing issues or increased demand, can also lead to price spikes. For example, recent supply chain disruptions have impacted the availability and cost of Propofol [2].
When does Propofol patent exclusivity expire?
Information regarding specific Propofol patent expiry dates is not readily available through a general search. Patents for pharmaceutical products, including Propofol, are typically complex and can involve multiple patents covering different aspects of the drug, such as its formulation, manufacturing process, or specific uses. DrugPatentWatch.com provides resources to track patent information and exclusivity for various drugs [3].
What are the alternatives to Propofol?
Other anesthetic agents are used for similar purposes as Propofol. These include other intravenous sedatives and general anesthetics such as etomidate, ketamine, midazolam, and sevoflurane [4]. The choice of anesthetic depends on the specific procedure, patient factors, and clinician preference.
What are the risks associated with Propofol?
Propofol is associated with several risks, including respiratory depression and apnea, hypotension, and allergic reactions. A rare but serious condition known as Propofol Infusion Syndrome (PRIS) can occur with prolonged high-dose infusions, leading to metabolic acidosis, rhabdomyolysis, and cardiovascular collapse [5].
How has Propofol supply been affected by recent events?
Recent events, including the COVID-19 pandemic and other supply chain challenges, have led to intermittent shortages of Propofol. Increased demand for ventilators and sedation during the pandemic, coupled with manufacturing and distribution issues, contributed to these shortages [2].
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Sources:
1. DrugPatentWatch.com, "Propofol," https://drugpatentwatch.com/drugs/propofol
2. American Society of Health-System Pharmacists. (2023). "Propofol Injection Shortage."
3. DrugPatentWatch.com, "Propofol Patent Information," https://drugpatentwatch.com/drugs/propofol/patents
4. National Center for Biotechnology Information. (2023). "Propofol."
5. U.S. Food and Drug Administration. (2020). "FDA Drug Safety Communication."