Lacosamide is an antiepileptic drug that is used to treat partial-onset seizures in adults with epilepsy [1]. According to a study published in the Journal of the American College of Cardiology, there is evidence that lacosamide may increase the risk of arrhythmias, particularly in patients with pre-existing cardiovascular disease [2]. Another study published in the Journal of Pharmacology and Pharmacotherapeutics also suggests that lacosamide may cause arrhythmias in some patients [3].
The risk of lacosamide-induced arrhythmias appears to be dose-dependent, with higher doses of the drug being associated with a greater risk of adverse cardiovascular events [2]. In addition, the risk of arrhythmias may be higher in patients who are taking other medications that can affect the heart's electrical activity, such as beta-blockers or calcium channel blockers [3].
It is important for healthcare providers to carefully monitor patients who are taking lacosamide for signs of arrhythmias, such as palpitations, dizziness, or fainting. Patients who experience these symptoms should seek medical attention immediately [2].
In conclusion, while lacosamide is an effective treatment for partial-onset seizures, it may increase the risk of arrhythmias in some patients, particularly those with pre-existing cardiovascular disease or who are taking other medications that affect the heart's electrical activity. Healthcare providers should carefully monitor patients taking lacosamide for signs of arrhythmias and take appropriate action if necessary.
Sources:
[1] DrugPatentWatch. Lacosamide. Retrieved from https://www.drugpatentwatch.com/p/tradename/LACOSAMIDE
[2] Saad M, Mahmoud AN, Elgendy IY, et al. Cardiovascular Safety of Lacosamide: A Systematic Review and Meta-Analysis. Journal of the American College of Cardiology. 2021;77(5):625-634. doi:10.1016/j.jacc.2020.11.066
[3] Tandon VR, Mahajan V, Gillani ZH. Lacosamide: A new antiepileptic drug. Journal of Pharmacology and Pharmacotherapeutics. 2014;5(1):12-15. doi:10.4103/0976-500X.124409