Lyrica (pregabalin) can interact with other medications, so it is important to consult with a healthcare provider before taking it with other drugs. Some medications that may interact with Lyrica include opioids, certain antidepressants, sedatives, and drugs that affect the central nervous system. These interactions can lead to increased side effects or reduced effectiveness of one or both medications. It is crucial to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements, to avoid potential interactions and ensure safe and effective treatment. [1][2][3]

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LYRICA
[2] https://www.goodrx.com/pregabalin/interactions
[3] https://www.drugs.com/drug-interactions/pregabalin,lyrica.html