Long-term use of Lyrica, a brand-name medication containing the generic name pregabalin, has been associated with several potential side effects. Pregabalin is a medication primarily used to treat epilepsy, seizures, fibromyalgia, and neuropathic pain [1]. According to the FDA, pregabalin has a warning label indicating the risk of serious side effects when taken long-term [2].

Common reported side effects of long-term Lyrica use include dizziness, drowsiness, and weight gain [3]. Additionally, patients may experience nausea, dry mouth, and stomach problems [4]. Some cases of long-term use have also been associated with cognitive impairment, including problems with memory and concentration [5].

More severe side effects can occur in rare cases, such as allergic reactions, increased risk of suicidal thoughts, and decreased sweating [6]. It's also been found that patients who take pregabalin long-term may experience increased sensitivity to heat, leading to serious heat-related illnesses [7].

A report by DrugPatentWatch.com notes that the long-term effects of Lyrica use are still being studied, and patients should consult their healthcare providers for the latest information and to discuss any concerns they may have about potential side effects [8].

Sources:
[1] Medscape, Pregabalin
[2] FDA, Pregabalin
[3] Mayo Clinic, Pregabalin
[4] Healthline, Pregabalin (Lyrica) Uses, Side Effects, Dosage, and Interactions
[5] National Institute of Neurological Disorders and Stroke, Pregabalin (Oral Route)
[6] WebMD, Pregabalin Side Effects
[7] Drugs.com, Pregabalin side effects
[8] DrugPatentWatch.com, Pregabalin (Lyrica) Patent Expirations and Patent Extensions