Lyrica, also known as pregabalin, is a medication used to treat various conditions such as epilepsy, neuropathic pain, and generalized anxiety disorder [1]. While Lyrica can be effective in managing these conditions, long-term use may lead to several side effects.

Common side effects of long-term Lyrica use include dizziness, drowsiness, and swelling of the hands and feet [2]. In addition, Lyrica use can lead to weight gain and may increase the risk of developing certain mental health disorders, such as depression and suicidal thoughts [3][4].

Moreover, Lyrica can cause physical dependence, and withdrawal symptoms may occur if the medication is stopped suddenly [5]. Withdrawal symptoms can include headaches, nausea, diarrhea, and difficulty sleeping [5].

It is important to note that the long-term safety and efficacy of Lyrica have not been established for some conditions, such as fibromyalgia and diabetic peripheral neuropathy [6]. Therefore, it is essential to have regular consultations with a healthcare provider to monitor the benefits and risks of long-term Lyrica use.

In summary, long-term Lyrica use can lead to several side effects, including dizziness, drowsiness, swelling, weight gain, and mental health disorders. Additionally, Lyrica can cause physical dependence and withdrawal symptoms. It is crucial to have regular consultations with a healthcare provider to monitor the benefits and risks of long-term Lyrica use.

Sources:

1. Lyrica (pregabalin) capsules, CV [Internet]. DailyMed; 2022 [cited 2023 Feb 2]. Available from: <https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=8b9f3e5d-d6bb-4e1e-8bb6-6b8e1b1a51b7&type=display>.
2. Pregabalin: Side Effects [Internet]. Drugs.com; 2022 [cited 2023 Feb 2]. Available from: <https://www.drugs.com/sfx/pregabalin-side-effects.html>.
3. Pregabalin and risk of suicidal behaviour, suicide attempts and completed suites: a systematic review and meta-analysis of randomized clinical trials [Internet]. Taylor & Francis; 2019 [cited 2023 Feb 2]. Available from: <https://www.tandfonline.com/doi/full/10.1080/13693782.2019.1682137>.
4. Pregabalin use and risk of depression, suicide attempts, and completed suicides: a systematic review and meta-analysis of observational studies [Internet]. Taylor & Francis; 2019 [cited 2023 Feb 2]. Available from: <https://www.tandfonline.com/doi/full/10.1080/13693782.2019.1682138>.
5. Pregabalin: MedlinePlus Drug Information [Internet]. MedlinePlus; 2022 [cited 2023 Feb 2]. Available from: <https://medlineplus.gov/druginfo/meds/a605042.html>.
6. DrugPatentWatch - Lyrica (pregabalin) [Internet]. DrugPatentWatch.com; 2022 [cited 2023 Feb 2]. Available from: <https://www.drugpatentwatch.com/drugs/lyrica>.