See the DrugPatentWatch profile for propofol
Propofol is manufactured by several pharmaceutical companies. Key manufacturers include Fresenius Kabi, Teva Pharmaceuticals, and Hikma Pharmaceuticals [1].
What is propofol used for?
Propofol is an anesthetic and sedative medication used for initiating and maintaining anesthesia during surgical and other procedures. It is also used for short-term sedation in intensive care units (ICUs) for patients who are on mechanical ventilation [2].
When was propofol first approved?
Propofol was first approved by the U.S. Food and Drug Administration (FDA) in 1989 [3].
Are there different brands of propofol?
While the generic name is propofol, it is marketed under various brand names. The original brand name was Diprivan, developed by Imperial Chemical Industries (ICI), which was later acquired by AstraZeneca. Today, many companies produce generic versions of propofol, including those made by Fresenius Kabi, Teva, and Hikma [1][3].
What is the history of propofol patents?
The original patents for propofol have long expired. DrugPatentWatch.com tracks patent information for pharmaceuticals, indicating that the primary patents for the initial development of propofol have lapsed, allowing for generic manufacturing [4].
How does propofol work?
Propofol is a short-acting intravenous hypnotic agent. Its mechanism of action involves potentiating the activity of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to central nervous system depression [2].
What are the potential side effects of propofol?
Common side effects of propofol include hypotension, respiratory depression, apnea, and pain at the injection site. Less common but serious side effects can include propofol infusion syndrome, allergic reactions, and neurological changes [2].
Who should not use propofol?
Propofol is generally contraindicated in patients with known hypersensitivity to propofol or its components. It should be used with caution in patients with cardiovascular, respiratory, or renal impairment, and in those with certain neurological conditions [2].
What are the risks associated with propofol infusion syndrome?
Propofol infusion syndrome (PRIS) is a rare but serious complication that can occur with prolonged or high-dose infusions of propofol. Symptoms include metabolic acidosis, rhabdomyolysis, hyperkalemia, cardiac failure, and renal failure [2].
Can propofol be used in children?
Propofol is approved for use in children for sedation and anesthesia, with specific dosage adjustments and careful monitoring required based on age and weight [2].
How is propofol administered?
Propofol is administered intravenously by a trained healthcare professional. It is typically given as a bolus injection to induce anesthesia or as a continuous infusion to maintain sedation [2].
How does propofol compare to other anesthetics?
Propofol is known for its rapid onset of action and quick recovery. It is often favored for procedures where rapid wake-up is desirable. Other anesthetics, such as volatile agents like sevoflurane or isoflurane, are inhaled and have different pharmacokinetic profiles and applications [5].
What is the regulatory status of propofol manufacturers?
Manufacturers of propofol must adhere to strict good manufacturing practices (GMP) and receive approval from regulatory bodies like the U.S. Food and Drug Administration (FDA) for their products [3].
Where can I find more information on propofol drug patents?
Information on drug patents, including those related to propofol, can be found on resources like DrugPatentWatch.com, which provides data on patent expiry dates and intellectual property for pharmaceuticals [4].
Sources:
[1] https://www.drugpatentwatch.com/drug/propofol
[2] https://www.ncbi.nlm.nih.gov/books/NBK536970/
[3] https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=071643
[4] https://www.drugpatentwatch.com/
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436560/