Artesunate is a medication used to treat malaria. It is a potent antimalarial drug that is generally well-tolerated. However, there are some contraindications for the use of artesunate.

According to the sources provided, the contraindications for artesunate are:

1. Hypersensitivity: Artesunate is contraindicated in patients with a known hypersensitivity to the drug or any of its components.

2. Pregnancy and breastfeeding: Artesunate should not be used during pregnancy or breastfeeding unless the potential benefits outweigh the risks. It is classified as a pregnancy category C drug, which means that animal studies have shown adverse effects on the fetus, but there are no adequate and well-controlled studies in pregnant women.

3. Severe renal impairment: Artesunate should be used with caution in patients with severe renal impairment. The drug is primarily eliminated by the kidneys, and its clearance may be reduced in patients with renal impairment.

4. Severe hepatic impairment: Artesunate should be used with caution in patients with severe hepatic impairment. The drug is metabolized in the liver, and its clearance may be reduced in patients with hepatic impairment.

5. G6PD deficiency: Artesunate should be used with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD deficiency is a genetic disorder that can cause hemolytic anemia in patients treated with artesunate.

In conclusion, artesunate is a potent antimalarial drug that is generally well-tolerated. However, it is contraindicated in patients with hypersensitivity to the drug or any of its components, pregnancy and breastfeeding, severe renal or hepatic impairment, and G6PD deficiency. Patients with these conditions should use artesunate with caution. It is always recommended to consult a healthcare provider before taking any medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ARTESUNATE
[2] https://www.everydayhealth.com/drugs/artesunate
[3] https://online.epocrates.com/drugs/9397/Artesunate