Can Lyrica (pregabalin) cause memory problems?
Yes. Lyrica (pregabalin) can affect thinking and recall in some people. Its side effects can include “difficulty concentrating,” “confusion,” and other cognitive effects that may feel like memory problems, especially early in treatment or after dose increases [1].
What kinds of “memory issues” are reported?
People may describe symptoms such as trouble concentrating, forgetfulness, brain fog, or slowed thinking. These can overlap with other nervous-system side effects (like dizziness or sleepiness), which can indirectly make memory feel worse [1].
How soon do memory/cognitive side effects show up?
Cognitive side effects can occur soon after starting Lyrica or after increasing the dose. They may improve if the dose is reduced, the medication is stopped under medical guidance, or time passes as the body adjusts [1].
Who is more likely to notice cognitive side effects?
Risk can be higher when Lyrica is started at a higher dose or increased quickly, and in people who are also taking other medications that affect the brain (for example, other sedatives). Older adults may be more sensitive to impairment from drugs like pregabalin [1].
What should you do if memory problems happen?
If you notice new or worsening confusion, marked forgetfulness, or significant concentration problems, contact the prescriber promptly. The typical next step is to review the dose and other medications and consider dose adjustment or a change in therapy [1].
When is it urgent?
Seek urgent medical help if confusion is severe, rapidly worsening, or comes with other serious symptoms (such as fainting, severe drowsiness, or trouble breathing). These can indicate a more serious reaction or interaction.
Are there alternatives if Lyrica affects memory?
Your prescriber may consider different doses or alternative treatments for the condition Lyrica was prescribed for (for example, neuropathic pain or seizures), depending on your diagnosis and medical history [1].
Sources
- FDA. “Lyrica (pregabalin) prescribing information.” https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=203915