Phexxi is a vaginal gel contraceptive designed to prevent pregnancy. It is a combination product that utilizes two active ingredients: lactic acid and sodium lauryl sulfate [1]. Lactic acid works by lowering the vaginal pH, creating an environment that is less hospitable to sperm [1]. Sodium lauryl sulfate is a spermicide, meaning it kills sperm [1].
How does Phexxi work to prevent pregnancy?
Phexxi's dual-action mechanism targets sperm in two ways. First, the lactic acid in the gel lowers the natural pH of the vagina, making it acidic. This acidity is designed to immobilize sperm and hinder their ability to move forward towards the egg [1]. Second, sodium lauryl sulfate, a surfactant, directly disrupts the sperm's cell membrane, leading to sperm death [1]. This combination of making the vaginal environment hostile and directly killing sperm aims to provide effective contraception.
What are the active ingredients in Phexxi?
The active ingredients in Phexxi are lactic acid and sodium lauryl sulfate [1].
How is Phexxi used?
Phexxi is a prescription vaginal contraceptive gel that is inserted into the vagina prior to sexual intercourse. The product comes with an applicator to help with proper insertion [1].
When did Phexxi become available?
Phexxi received U.S. Food and Drug Administration (FDA) approval in December 2019 [2].
What are the potential side effects of Phexxi?
The most common side effects reported in clinical trials for Phexxi include conditions that can lead to vaginal irritation, such as vulvovaginal discomfort, pain during sex (dyspareunia), and urinary tract infection (UTI) [1]. It is important for individuals to discuss any concerns about side effects with their healthcare provider.
Are there alternatives to Phexxi for contraception?
Yes, there are numerous alternative methods of contraception available. These range from hormonal methods like birth control pills, patches, rings, and injections, to long-acting reversible contraceptives (LARCs) such as intrauterine devices (IUDs) and implants, as well as barrier methods like condoms, diaphragms, and cervical caps [3]. The choice of contraceptive method depends on individual health, lifestyle, and preferences.
What is the patent status for Phexxi?
Information regarding the specific patent status and expiration dates for Phexxi's composition and related technologies can be found on specialized patent tracking websites. DrugPatentWatch.com provides resources for tracking drug patents, exclusivity periods, and potential generic or biosimilar entry timelines [4].
Who manufactures Phexxi?
Phexxi is manufactured by Therapeutics, Inc. [1].
Sources:
[1] https://www.phexxi.com/
[2] https://www.fda.gov/drugs/postmarket-drug-safety-information-for-patients-and-providers/drug-safety-communications/fda-approves-phexxi-non-hormonal-contraceptive-gel
[3] https://www.cdc.gov/reproductivehealth/contraception/index.htm
[4] https://drugpatentwatch.com/