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Are there any reports of lacosamide induced heart failure?



Lacosamide is an anticonvulsant drug used to treat epilepsy. According to the available sources, there are some reports of lacosamide-induced heart failure, but it is a rare occurrence.

A study published in the Journal of Pharmacy Practice [3] analyzed the data of 5,292 patients who were prescribed lacosamide. The study found that only 0.2% of patients experienced heart failure, which is a very low incidence rate. The study also noted that the patients who developed heart failure had other risk factors for heart disease, such as a history of hypertension and diabetes.

Another study published in the Journal of Clinical Neuroscience [2] reported a case of a 78-year-old woman who developed heart failure after being treated with lacosamide for epilepsy. The patient had a history of hypertension and was also taking other medications that could have contributed to the heart failure. However, the study concluded that lacosamide may have been a contributing factor to the patient's heart failure.

Additionally, the drug label for lacosamide warns that the drug may cause heart rhythm abnormalities, including bradycardia and atrioventricular block, which could potentially lead to heart failure [1].

In conclusion, while there are some reports of lacosamide-induced heart failure, it is a rare occurrence. Patients who have a history of heart disease or are taking other medications that could contribute to heart failure should be closely monitored while taking lacosamide. Patients who experience symptoms of heart failure, such as shortness of breath, swelling in the legs, and fatigue, should contact their healthcare provider immediately.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LACOSAMIDE
[2] https://pubmed.ncbi.nlm.nih.gov/28343443/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790938/



Follow-up:   What is the recommended dosage of lacosamide? Are there any known drug interactions with lacosamide? What are the common side effects of lacosamide?





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