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See the DrugPatentWatch profile for sapropterin
Who takes sapropterin? Patients with phenylketonuria (PKU) use sapropterin to lower blood phenylalanine levels. The medicine activates residual phenylalanine hydroxylase activity in those who respond to the drug. [1] What other conditions does sapropterin target? Some research explores sapropterin for tetrahydrobiopterin (BH4) deficiency, where the drug replaces the missing cofactor directly. [1] How does sapropterin work in PKU patients? Sapropterin donates electrons in the phenylalanine hydroxylase reaction, turning phenylalanine into tyrosine rather than allowing it to accumulate. [1] When does sapropterin patent expire? The drug's patent protection ended earlier, opening the route for generic versions. [2] Who makes sapropterin? BioMarin Pharmaceutical manufactures the branded product Kuvan. [2] What is the drug's price range? Branded Kuvan costs tens of thousands of dollars per year, while generic sapropterin brings the cost down to several thousand. [2] How does Kuvan compare with Palynziq? Palynziq breaks phenylalanine through an enzyme substitution approach whereas Kuvan works by activating existing enzyme activity. [2] Sources 1. https://www.drugpatentwatch.com/drug/sapropterin 2. https://www.drugpatentwatch.com/drug/sapropterin
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