Generic versions of Entresto are not yet available in the United States [1]. The drug, which combines sacubitril and valsartan, is currently protected by patents [2].
When does the Entresto patent expire?
The primary patents for Entresto are set to expire in 2025 [2]. However, there are other patents related to the drug that extend further, with some expiring in 2031 [2]. These later patents may influence when generic competition can emerge.
Who manufactures Entresto?
Entresto is manufactured by Novartis [3].
Why are companies challenging this patent?
Companies often challenge drug patents to pave the way for generic versions to enter the market sooner, which can lead to lower drug prices [4]. The specific reasons for patent challenges are typically detailed in legal filings and are not publicly available without further investigation.
How does Entresto work?
Entresto is a prescription medication used to treat heart failure with reduced ejection fraction [5]. It works by combining sacubitril, which inhibits neprilysin, and valsartan, an angiotensin II receptor blocker [5]. This dual action helps to relax blood vessels, reduce blood volume, and decrease salt and water retention, thereby improving heart function [5].
What are the side effects of Entresto?
Common side effects of Entresto include low blood pressure, high potassium levels, cough, dizziness, and kidney problems [5]. Patients should discuss any concerns about side effects with their healthcare provider.
Can biosimilars enter before patent expiry?
Entresto is a small molecule drug, not a biologic. Therefore, the term "biosimilar" does not apply. Generic versions of small molecule drugs can enter the market after patent expiry and regulatory approval, provided no other exclusivity periods are in place [6].
What is the price of Entresto?
The price of Entresto can vary depending on insurance coverage and pharmacy. Information on current pricing is best obtained from pharmacies or by checking insurance formularies. Generic availability typically leads to significant price reductions for medications.
What is the difference between Entresto and generic alternatives?
Currently, there are no generic alternatives to Entresto available in the United States [1]. Once generic versions become available, they are expected to be chemically identical to the brand-name drug and would offer a lower-cost option for patients [6].
Sources:
[1] https://www.drugpatentwatch.com/
[2] https://www.drugpatentwatch.com/
[3] https://www.novartis.com/
[4] https://www.drugpatentwatch.com/
[5] https://www.entresto.com/
[6] https://www.fda.gov/