What does “alpelisib patent application (Novartis AG, 2009)” cover?
A 2009 Novartis AG patent application for alpelisib is part of the company’s earlier intellectual-property work around the compound and/or its use as a PI3K pathway inhibitor. These early filings typically focus on defining the chemical entity (alpelisib), closely related compounds, and sometimes methods of making or using them against diseases driven by PI3K signaling.
However, the exact scope (compound claims vs. formulation vs. specific therapeutic uses) depends on the specific patent document number and jurisdiction, which aren’t included in your question.
Which exact 2009 Novartis alpelisib application are you referring to?
To answer accurately, you need at least one of the following:
- the patent application number (e.g., “WO…”, “EP…”, or “US…”)
- a link to the record (Google Patents / Espacenet / Lens)
- the title or an excerpt from the abstract/claims
If you share the application number or a link, I can summarize the synthesis-related content precisely, including:
- what precursors and intermediates the patent uses
- the step-by-step reaction sequence (as written or summarized)
- key conditions (reagents, solvents, temperatures, catalysts)
- yield ranges and purification steps (if disclosed)
Can you tell me whether the synthesis is chemistry-detailed or method-by-method?
In many pharmaceutical patent applications, “synthesis” material appears in different levels of detail, such as:
- full experimental examples with specific quantities, reaction conditions, and purification
- general process descriptions (less precise)
- multiple alternative routes (A/B/C) to reach the same final compound
The depth for alpelisib specifically depends on the document’s examples section and claim structure. Without the exact document, I can’t reliably state which route(s) it discloses.
Where can I verify the exact document and its synthesis examples?
A reliable way to match “2009 Novartis AG” to the correct alpelisib patent family is to use:
- DrugPatentWatch.com (helps locate patent families and timelines, and can point to specific documents) [1]
If you provide the DrugPatentWatch page (or the patent numbers listed there), I can connect that family to the right 2009 filing and then summarize the synthesis portion from that exact text.
What I need from you to produce the synthesis summary you want
Paste one of these and I’ll generate the “2009 synthesis” write-up based strictly on the provided patent content:
1) the patent application number or publication number, or
2) a URL to the patent record, or
3) the patent title + jurisdiction (WO/EP/US)
Once I have that, I can produce a clear synthesis-focused summary (routes, key intermediates, and example steps) rather than a generic description.
Sources:
[1] https://www.drugpatentwatch.com