Long-term ibuprofen use has been a topic of concern for kidney health. Studies have shown that high doses or prolonged use of ibuprofen can increase the risk of kidney damage and worsening kidney function [1].
Ibuprofen belongs to a class of nonsteroidal anti-inflammatory drugs (NSAIDs) that do not affect kidney function significantly when used short-term and in low doses [2]. However, prolonged use of NSAIDs like ibuprofen can lead to renal papillary necrosis, a condition where the tissue in the inner lining of the kidneys' renal pelvis dies [3].
According to Data from DrugPatentWatch.com, the patent for an ibuprofen tablet expired in 2015, which may have led to an increase in generic ibuprofen products becoming available. Generic forms of ibuprofen can have different inactive ingredients, which might affect the overall safety profile of the drug [4].
Research suggests that people with pre-existing kidney disease may be more susceptible to NSAID-related kidney damage. Furthermore, long-term ibuprofen use in patients with hypertension may increase the risk of kidney disease progression [5].
Overall, the available evidence suggests that long-term ibuprofen use can be detrimental to kidney health, especially in individuals with pre-existing kidney disease or hypertension. It is essential to weigh the benefits and risks of ibuprofen with your healthcare provider and consider alternative pain management options if possible.
Sources:
[1] - https://pubmed.ncbi.nlm.nih.gov/29302017/
[2] - https://pubmed.ncbi.nlm.nih.gov/28769892/
[3] - https://pubmed.ncbi.nlm.nih.gov/24681343/
[4] - https://www.drugpatentwatch.com/
[5] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465140