What side effects can Lyrica (pregabalin) cause?
Common side effects include dizziness, sleepiness (somnolence), and tiredness/fatigue. People also report blurred vision, trouble with coordination, and weight gain. Some experience swelling in the legs or feet (edema) [1].
What more serious side effects should you watch for?
Lyrica can cause serious reactions in some people. Get urgent medical help if you develop signs of an allergic reaction (such as swelling of the face/lips or trouble breathing). It can also increase the risk of severe drowsiness or breathing problems, especially in people taking other medicines that slow the nervous system [1].
What are the risks when Lyrica is combined with other medications?
Taking Lyrica with other sedating or respiratory-depressing drugs increases the chance of excessive drowsiness and breathing issues. This includes opioids and medicines that cause sedation (for example, some sleep medicines, benzodiazepines, and other anti-anxiety drugs) [1].
Who is more likely to get side effects?
Side effects are more likely when starting treatment or increasing the dose, and when Lyrica is taken with other medications that make you sleepy. Older adults may be more sensitive to dizziness and falls, and people with kidney problems may have higher exposure if the dose is not adjusted [1].
What should you do if you get a side effect?
If side effects are mild (like temporary dizziness or sleepiness), many people can manage by using the prescribed dose and avoiding driving or alcohol until you know how it affects you. If symptoms are severe, getting worse, or include swelling, rash, or breathing trouble, contact a clinician right away. Do not stop suddenly without medical advice [1].
How long do Lyrica side effects last?
Dizziness and sleepiness often show up early and may lessen as your body adjusts, though not for everyone. Persistent or worsening effects should be discussed with your prescriber so they can consider dose adjustment or switching treatments [1].
Can Lyrica cause dependency or withdrawal?
Lyrica is a controlled medication in some settings, and stopping abruptly can lead to withdrawal-like symptoms in some patients. If you want to stop or switch, ask your prescriber about a taper plan [1].
Are there differences between Lyrica and generic pregabalin?
Lyrica is the brand name for pregabalin. Generic pregabalin should have the same active ingredient and is expected to have similar side effects [1].
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Sources
[1] https://www.ema.europa.eu/en/medicines/human/EPAR/lyrica