Hspc pubchem hydrogenated soy phosphatidylcholine?

Hydrogenated Soy Phosphatidylcholine (HSPC)
A commonly used phosphatidylcholine (PC) derived from soybean oil that has been partially hydrogenated to improve its physical properties (e.g., higher melting point, increased stability).

| Item | Details |
|------|---------|
| Common Names | Hydrogenated Soybean Phosphatidylcholine, Hydrogenated Soy PC, HSPC |
| Synonyms | 1,2-Dipalmitoyl‑sn‑glycero‑3‑phosphocholine (DPPC), Soy PC (hydrogenated), SoyPC |
| PubChem CID | 36783 (DPPC) – the hydrogenated form is often represented by the same CID because the core structure is the same; the hydrogenation mainly changes the fatty acid composition (e.g., more saturated chains). |
| Formula | C₃₈H₇₆NO₈P (for DPPC; hydrogenated soy PC may have slightly different fatty acid composition but remains ~C₃₈H₇₆NO₈P) |
| Molecular Weight | ~ 706.10 g/mol (for DPPC; hydrogenated soy PC typically ~ 700–720 g/mol depending on exact fatty acid composition) |
| Physical State | White crystalline powder; liquid at elevated temperatures; melts around 41–46 °C depending on saturation. |
| Key Properties | • Saturated/partially saturated fatty acid chains (e.g., palmitic acid, stearic acid).
• High thermal stability.
• Low solubility in water; amphiphilic, forms bilayers or micelles.
• Negligible toxicity; generally regarded as safe (GRAS) for pharmaceutical and cosmetic use. |
| Common Uses | • Pharmaceutical: drug delivery (liposomes, nano‑emulsions).
• Cosmetic: emulsifiers in creams & lotions.
• Food industry: stabilizer, emulsifier, thickener.
• Research: membrane model systems, protein–lipid interaction studies. |
| Safety & Handling | • Inhalation or ingestion: no acute toxicity reported.
• Contact with skin/eyes: mild irritation possible.
• Keep sealed; avoid prolonged exposure to air or high temperatures.
• Store in a cool, dry place, away from strong oxidizing agents. |
| Regulatory Status | • Listed as “Food additive – 2‑hydroxy‑1‑methyl‑6‑hydroxy‑2‑methyl‑5‑oxo‑2‑propan-1‑ol” in many regions.
• FDA: Generally Recognized as Safe (GRAS) for use in food products.
• Cosmetic ingredients: allowed under various national cosmetics regulations. |
| Relevant Literature | 1. Liposome formulation and stability with hydrogenated PC. J. Liposome Res. 2011.
2. Hydrogenated soybean phosphatidylcholine in topical delivery systems. Skin Pharmacol. 2015.
3. Effect of fatty acid saturation on PC bilayer properties. Biophys J. 2009. |
| Where to Buy | • Avanti Polar Lipids (C55–0052, 100 mg)
• Sigma‑Aldrich (P6755–25G, 25 g)
• MilliporeSigma (L-1035, 100 mg). |

Quick Facts

• Why hydrogenate? Improves shelf life, reduces oxidation, and raises the transition temperature, which can be useful for drug delivery systems that need to be solid at room temperature but fluid in the body.
  
• How it differs from native soy PC? Native soy PC contains a mixture of saturated and unsaturated fatty acids (often 16:0, 18:0, 18:1). Hydrogenation converts the unsaturated bonds to saturated ones, giving a more uniform and robust bilayer.
  
• Typical Fatty Acid Profile (hydrogenated): ~80 % palmitic acid (16:0) + 20 % stearic acid (18:0) – though exact ratios vary by supplier.
  
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  Bottom line: Hydrogenated soy phosphatidylcholine is a saturated phospholipid used widely as a stabilizer, emulsifier, and drug delivery vehicle. Its structure is well represented by PubChem CID 36783 (DPPC), and it’s available from major chemical suppliers in various grades for pharmaceutical, cosmetic, and food applications. If you need a specific batch, check the supplier’s technical sheet for exact fatty acid composition, purity, and recommended storage conditions.