Most Common Side Effects of Rinvoq
Rinvoq (upadacitinib), a JAK inhibitor for conditions like rheumatoid arthritis, psoriasis, and ulcerative colitis, most often causes upper respiratory tract infections (affecting 14-18% of users), nausea (6-11%), headache (6-9%), acne (5-7%), and elevated creatine phosphokinase levels (4-6%). These rates vary by indication and dosage; for example, infections are more frequent in atopic dermatitis patients.[1][2]
Side Effects by Condition
- Rheumatoid Arthritis: Upper respiratory infections top the list at 17%, followed by nausea (7%), headache (6%), and herpes zoster (1-4%).[2]
- Atopic Dermatitis: Infections rise to 24%, with acne (15%) and headache (7%) also common.[2]
- Ulcerative Colitis: Nausea (11%), bronchitis (10%), and anemia (8%) stand out.[2]
Patients on higher doses (30 mg) report more issues like elevated liver enzymes or weight gain.[1]
Serious Risks and Warnings
Serious infections like pneumonia or tuberculosis occur in 3-5% of users, with higher rates in those over 65 or on steroids. Other concerns include blood clots (0.3-1%), heart issues, cancer risk, and gastrointestinal tears. Black box warnings cover infections, clots, heart problems, cancer, and death. Monitoring includes TB tests before starting and regular blood work.[1][2]
What Happens If You Get These Side Effects?
Mild effects like nausea or headache often resolve without stopping treatment. Report persistent infections, severe pain, shortness of breath, or yellowing skin immediately—dose adjustments or discontinuation may be needed. Avoid live vaccines during use.[1]
Rinvoq vs. Similar Drugs
Compared to Humira (adalimumab), Rinvoq has higher infection rates but fewer injection-site reactions. Versus Xeljanz (tofacitinib), side effect profiles align closely as both are JAK inhibitors, though Rinvoq shows slightly more acne and nausea.[3]
Who Experiences More Side Effects?
Higher risk in older adults, smokers, or those with lung disease. Women report more nausea; dosage and duration increase overall incidence.[2]
[1]: Rinvoq Prescribing Information (AbbVie)
[2]: FDA Label for Rinvoq
[3]: Drugs.com - Rinvoq Side Effects