Yes—Lyrica (pregabalin) can affect workout performance for some people
Lyrica’s common side effects include dizziness and sleepiness, which can make training feel harder and reduce safety while exercising, especially activities that require balance, coordination, or quick reactions [1]. It can also cause fatigue, which may directly lower workout intensity and stamina [1].
What side effects are most likely to show up during training
If you notice performance changes after starting Lyrica, the most relevant side effects are usually:
- Dizziness or lightheadedness, which can affect balance and increase the risk of missteps during cardio, lifting, or drills [1].
- Sleepiness or reduced alertness, which can make warm-ups feel slower and reduce motivation or focus during sets [1].
- Fatigue, which can lower endurance and make normal workouts feel unusually taxing [1].
Does it get better over time, or does it persist?
For many people, early side effects can be strongest when starting the medication or after dose changes, then lessen as the body adjusts. If side effects persist or worsen, performance impact can continue and you may need to discuss dose timing or a different approach with your clinician [1].
Are there workout types that are riskier on Lyrica?
Workouts that demand steady balance and rapid coordination are the biggest concern if dizziness or drowsiness is present, such as:
- Running or high-impact cardio when you feel lightheaded
- Sports, plyometrics, or agility work if alertness is reduced
- Heavy lifting if you feel off-balance or mentally slowed
If dizziness or sleepiness is active, it’s safer to avoid pushing intensity and consider switching to lower-risk activity (for example, steady walking or controlled resistance work) until symptoms are controlled [1].
Can timing help—what people often try
Some people choose to schedule workouts at the time of day when they feel least drowsy (for example, after the period when dizziness/sleepiness is worst). Because Lyrica timing and dosing schedules vary, the safest approach is to track your symptoms in relation to your dose and bring that pattern to your prescriber [1].
When to get medical advice quickly
Contact a clinician promptly if you have side effects that clearly interfere with basic activities (not just training), or if you experience severe dizziness, fainting, or unusual weakness. These can increase the risk of injury during exercise [1].
Sources
[1] https://www.drugs.com/lyrica.html