Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation in the body. Atorvastatin, sold under the brand name Lipitor, is a medication used to lower cholesterol levels. When taking these two drugs together, there is a potential for drug interactions and side effects.

According to GoodRx [3], taking ibuprofen and atorvastatin together may increase the risk of developing rhabdomyolysis, a serious condition in which muscle tissue breaks down and releases proteins into the bloodstream, which can cause kidney damage. This risk is particularly high for people who are elderly, have kidney disease, or are taking high doses of atorvastatin.

Additionally, ibuprofen can interfere with the anti-inflammatory effects of atorvastatin, reducing its effectiveness [3]. This could potentially lead to increased cholesterol levels and a higher risk of heart disease.

Another potential side effect of taking ibuprofen and atorvastatin together is an increased risk of gastrointestinal bleeding and ulcers [1]. Ibuprofen is known to irritate the lining of the stomach, and combining it with atorvastatin can increase the risk of bleeding and ulcers.

Ginkgo biloba, an herbal supplement that is sometimes used to improve cognitive function, can also interact with atorvastatin [2]. Ginkgo can increase the risk of bleeding, which can be exacerbated when combined with ibuprofen and atorvastatin.

In conclusion, taking ibuprofen and atorvastatin together can increase the risk of rhabdomyolysis, interfere with the anti-inflammatory effects of atorvastatin, and increase the risk of gastrointestinal bleeding and ulcers. It is important to speak with a healthcare provider before taking these medications together or adding any new supplements to your regimen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/IBUPROFEN
[2] https://www.mayoclinic.org/drugs-supplements-ginkgo/art-20362032
[3] https://www.goodrx.com/atorvastatin/interactions