What's in entresto?

Entresto is a fixed‑dose prescription medicine made of two active ingredients:

- Sacubitril (a neprilysin inhibitor; prodrug converted to LBQ657)
- Valsartan (an angiotensin II receptor blocker, ARB)

Together, they help relax blood vessels and reduce strain on the heart.

Common tablet strengths (taken twice daily) are:
- 24 mg sacubitril / 26 mg valsartan
- 49 mg / 51 mg
- 97 mg / 103 mg

The exact strength you take depends on your prior treatment and your doctor’s instructions. The tablets also contain inactive ingredients (excipients) that vary by strength; check the packaging or patient information leaflet for the full list.

If you’re considering Entresto or have questions about dosing, safety (e.g., risk of angioedema, pregnancy considerations), or drug interactions, talk to your healthcare provider.