Rexulti Dosing Information
Rexulti (brexpiprazole) is a medication used to treat schizophrenia and as an add-on treatment for major depressive disorder. Dosing varies based on the condition being treated and individual patient response.
How is Rexulti typically dosed for schizophrenia?
For schizophrenia, the starting dose of Rexulti is usually 1 mg orally once daily. This may be titrated up to a target dose of 4 mg orally once daily, with dosage increases made at weekly intervals. Doses can be increased by 1 mg at a time weekly, based on clinical judgment and patient tolerability [1].
What is the recommended Rexulti dosage for depression?
When used as an add-on treatment for major depressive disorder, the starting dose of Rexulti is also typically 1 mg orally once daily. Similar to schizophrenia treatment, this dose can be titrated up to a target dose of 4 mg orally once daily. Dosage increases should occur at weekly intervals, moving up by 1 mg at a time, guided by clinical assessment and how well the patient tolerates the medication [1].
Are there any dose adjustments needed for Rexulti?
Dose adjustments for Rexulti may be necessary due to interactions with other medications or specific patient factors. For example, if co-administered with strong cytochrome P450 3A4 (CYP3A4) inhibitors, the Rexulti dose should be reduced [1]. Conversely, if co-administered with strong CYP2D6 inhibitors, the dose should be increased [1].
What are the potential side effects to watch for with Rexulti?
Common side effects of Rexulti include akathisia (a movement disorder characterized by restlessness), weight gain, and somnolence. Other potential side effects can include insomnia, headache, and nausea [1]. Patients should report any new or worsening symptoms to their healthcare provider.
How long does it take for Rexulti to work?
The time it takes for Rexulti to become effective can vary among individuals. For schizophrenia, improvements in symptoms may be observed within the first few weeks of treatment. For major depressive disorder, when used as an add-on therapy, it may take several weeks to notice a significant improvement in depressive symptoms [1].
What happens if a dose of Rexulti is missed?
If a dose of Rexulti is missed, patients should take the next scheduled dose at the regular time. They should not double the dose to make up for a missed dose [1]. It is advisable to consult a healthcare professional for specific guidance regarding missed doses.