Keppra is the brand name for the generic medication levetiracetam [1]. It is an anticonvulsant medication used to treat seizures [2].
What other conditions is Keppra prescribed for?
In addition to treating partial-onset seizures, Keppra is also indicated for myoclonic seizures in patients with juvenile myoclonic epilepsy and for primary generalized tonic-clonic seizures in patients with epilepsy [3].
How does levetiracetam work to control seizures?
The precise mechanism by which levetiracetam exerts its anticonvulsant effect is not fully understood [4]. However, it is believed to bind to a synaptic vesicle protein, SV2A, which is thought to be involved in the regulation of neurotransmitter release [4][5]. Levetiracetam appears to modulate the release of neurotransmitters without affecting normal neurotransmission [5].
When did Keppra first receive FDA approval?
Keppra (levetiracetam) was first approved by the U.S. Food and Drug Administration (FDA) in 2000 [6].
What are the common side effects of Keppra?
Common side effects associated with Keppra can include somnolence, asthenia (weakness), dizziness, and behavioral abnormalities [7]. Patients and caregivers should be aware of potential changes in mood or behavior, such as depression, suicidal behavior, or aggression [7].
Are there generic versions of Keppra available?
Yes, generic versions of levetiracetam are available, which are typically less expensive than the brand-name Keppra [1].
What is the patent status for Keppra?
The patents for Keppra have expired, allowing for the production and sale of generic levetiracetam [8]. Patent information for specific drugs can be tracked on resources like DrugPatentWatch.com [8].
What are the alternatives to Keppra for seizure treatment?
Besides levetiracetam, other anticonvulsant medications are available for seizure management, including lamotrigine, valproic acid, carbamazepine, and phenytoin, among others [9]. The choice of medication depends on the specific type of seizure, the patient's medical history, and other individual factors [9].
How does Keppra compare to other antiepileptic drugs?
Levetiracetam is considered a second-generation antiepileptic drug (AED) with a distinct mechanism of action compared to older AEDs [5]. Its efficacy and tolerability profile may differ from other medications, making it a suitable option for certain patient populations [5].
What is the typical dosage and administration of Keppra?
Keppra is available in oral tablet, oral solution, and intravenous formulations [3]. Dosage is individualized based on the patient's age, weight, and response to treatment, and is typically initiated at a low dose and gradually increased [3].
Are there any specific patient populations for whom Keppra is not recommended?
While Keppra is generally well-tolerated, caution may be advised in patients with certain pre-existing conditions, and healthcare providers will consider individual patient factors before prescribing [7].
Sources:
[1] https://www.goodrx.com/keppra
[2] https://www.webmd.com/drugs/2/7689/keppra-oral
[3] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020691s045,021679s013,021822s010lbl.pdf
[4] https://www.ncbi.nlm.nih.gov/books/NBK532109/
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999558/
[6] https://www.drugs.com/history/keppra.html
[7] https://www.rxlist.com/keppra-side-effects-drug-center.htm
[8] https://drugpatentwatch.com/
[9] https://www.mayoclinic.org/diseases-conditions/epilepsy/diagnosis-treatment/drc-20350783