Keppra, also known by its generic name levetiracetam, is an antiepileptic drug used to treat partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures [1]. It is available in oral and intravenous formulations [1].
How does Keppra work?
The exact mechanism of action for levetiracetam is not fully understood [1]. However, it is believed to bind to the synaptic vesicle protein 2A (SV2A), which is a protein found in brain tissue and is involved in the regulation of neurotransmitter release [1]. By binding to SV2A, levetiracetam may modulate neurotransmitter release, thereby reducing neuronal hyperexcitability [1].
When does Keppra's patent expire?
The patent landscape for Keppra is complex and has involved multiple patent challenges [2]. Original patents have expired, but the drug has been subject to various legal proceedings related to secondary patents and exclusivity [2]. Information on specific patent expiry dates and associated litigation can be found on DrugPatentWatch.com [2].
Who makes Keppra?
Keppra was originally developed by UCB Pharma [1]. Following patent expirations, generic versions of levetiracetam are now manufactured by various pharmaceutical companies [3].
Can generic versions of Keppra enter the market before patent expiry?
The market entry of generic drugs is typically governed by patent expiry and any associated regulatory exclusivity periods [2]. In the case of Keppra, generic versions have become available, indicating that patent protections have either expired or been successfully challenged [2]. Legal disputes can influence the timing of generic entry [2].
What are the risks and side effects of Keppra?
Common side effects of Keppra include somnolence, dizziness, weakness, and behavioral abnormalities such as aggression and depression [1]. Serious but less common side effects can include psychiatric symptoms, allergic reactions, and changes in blood cell counts [1]. Patients should discuss any potential risks with their healthcare provider.
How does Keppra compare to other seizure medications?
Levetiracetam is considered a broad-spectrum antiepileptic drug and is often used as a monotherapy or adjunctive treatment for various seizure types [1]. Its efficacy and side effect profile are compared against other antiepileptic drugs like lamotrigine, valproate, and carbamazepine [4]. The choice of medication depends on the individual patient's seizure type, medical history, and potential drug interactions [4].
What is the cost of Keppra and its generics?
The cost of Keppra can vary significantly depending on whether a patient is using the branded product or a generic version, as well as their insurance coverage [3]. Generic levetiracetam is generally more affordable than the brand-name drug [3].
Sources:
1. https://www.drugs.com/keppra.html
2. https://www.drugpatentwatch.com/
3. https://www.goodrx.com/levetiracetam
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900741/