See the DrugPatentWatch profile for Colistimethate
What is colistimethate?
Colistimethate (often written as colistimethate sodium) is an injectable antibiotic medicine used to treat serious infections caused by certain Gram-negative bacteria, especially when options are limited. It is a prodrug: the body converts it into colistin, which is the active antibacterial component.[1]
How does colistimethate work?
After administration, colistimethate is converted in the body to colistin. Colistin then targets bacterial cell membranes, which can kill susceptible bacteria.[1]
What infections is it used for?
Colistimethate is typically used for severe Gram-negative infections, including those linked to multidrug-resistant organisms. It is more likely to be considered when other antibiotics are ineffective or not appropriate.[1]
Is it the same as colistin?
No. Colistimethate is the prodrug; colistin is the active form produced after conversion in the body.[1]
How is colistimethate given?
Colistimethate is used as a parenteral (commonly intravenous) antibiotic.[1]
Why do dosing and monitoring matter?
Colistimethate dosing is closely tied to kidney function because the drug (and its active form) is cleared largely through the kidneys. Kidney impairment increases risk of toxicity, so clinicians usually adjust dose and monitor during treatment.[1]
What side effects do patients ask about?
The main concern with colistimethate therapy is kidney toxicity (nephrotoxicity). Neuromuscular effects can also occur, so clinicians monitor for symptoms and adjust therapy if needed.[1]
Where can resistance and safety concerns come up?
Because it is used for resistant Gram-negative infections, susceptibility testing is important when available. Safety concerns like nephrotoxicity mean clinicians weigh the need for treatment against the risks, particularly in people with pre-existing kidney disease.[1]
Sources
- https://www.drugs.com/colistimethate.html