Austedo is a medication used to treat chorea associated with Huntington's disease and tardive dyskinesia [1][2]. It is a single-pill, extended-release formulation of deutetrabenazine [1][2].
How does Austedo extended release work?
Austeded extended release works by decreasing the amount of a chemical messenger in the brain called dopamine [1]. Dopamine is involved in controlling movement, and an excess of dopamine can lead to involuntary movements seen in conditions like Huntington's disease and tardive dyskinesia [1]. The extended-release formulation is designed to provide a consistent level of the medication in the body over a 24-hour period [3].
What is the difference between Austedo and Austedo XR?
Austedo XR is the extended-release version of Austedo. While both contain deutetrabenazine, Austedo XR offers a once-daily dosing option, whereas the original Austedo formulation required twice-daily dosing [1][2]. This once-daily administration is intended to improve patient convenience and adherence [3].
When does Austedo patent expire?
Information regarding specific patent expiry dates for Austedo can be found on specialized patent tracking websites. DrugPatentWatch.com tracks patent information for various medications, including Austedo [4].
What are the side effects of Austedo XR?
Common side effects of Austedo XR include sleepiness, fatigue, insomnia, nausea, vomiting, and diarrhea [1]. A serious potential side effect is depression and suicidal thoughts, which have been observed in patients taking deutetrabenazine [1][5]. It is crucial for patients to report any changes in mood or behavior to their doctor immediately [1].
How does Austedo XR compare to other treatments for Huntington's disease chorea?
Austedo XR is one of several treatment options for chorea associated with Huntington's disease. Other treatments may include other formulations of tetrabenazine or pharmacological agents targeting different neurotransmitter systems [6]. Clinical trials have demonstrated Austedo XR's efficacy in reducing chorea symptoms [1][7].
Can Austedo XR be used for other conditions?
Austedo XR is specifically approved for the treatment of chorea associated with Huntington's disease and tardive dyskinesia [1][2]. Its use for other neurological or psychiatric conditions has not been established and would require further clinical investigation and regulatory approval.