Skyrizi Cash Price Without Insurance
Skyrizi (risankizumab-rzaa), used for plaque psoriasis, Crohn's disease, and ulcerative colitis, costs $6,483 to $7,272 for a 30-day supply of the 150 mg/mL starter doses (two injections) at major U.S. pharmacies. A 90-day maintenance supply (three doses) runs $19,449 to $21,816. Prices vary by pharmacy, location, and quantity; check GoodRx for current deals, where starter doses average $6,483 after coupons.[1][2]
Factors Driving Skyrizi's High List Price
AbbVie sets the wholesale acquisition cost (WAC) at $6,790 per 150 mg dose. Actual cash payments fluctuate due to pharmacy markups (5-10%), state regulations, and 340B discounts for eligible providers. Without insurance, patients pay the full list price upfront.[1][3]
Ways to Lower Costs Without Insurance
- Discount Cards: GoodRx or SingleCare coupons drop starter doses to $5,500-$6,500; maintenance to $18,000-$20,000.[2][4]
- Manufacturer Savings: AbbVie's myAbbVie Assist offers up to $0 copay for uninsured patients earning under $100K (annual income), but requires application and covers only eligible fills.[5]
- Patient Assistance: NeedyMeds or RxAssist programs provide free or discounted Skyrizi for low-income uninsured adults.[6]
How Skyrizi Compares to Similar Drugs Cash Prices
Skyrizi is pricier than some rivals without insurance:
| Drug | Condition | 30-Day Cash Price (w/ coupon) |
|------|-----------|-------------------------------|
| Skyrizi | Psoriasis/Crohn's | $6,483 |
| Tremfya | Psoriasis | $5,987 |
| Stelara | Psoriasis/Crohn's | $5,456 |
| Cosentyx | Psoriasis | $4,987 |
| Humira | Psoriasis/Crohn's | $6,000+ |
Prices from GoodRx averages; biologics like these stay expensive due to patents expiring 2032-2035.[1][2][7]
When Does Skyrizi's Patent Expire?
Key U.S. patents on risankizumab expire in 2033 (composition) and 2035 (method of use), per DrugPatentWatch. No generics until then, though AbbVie faces Paragraph IV challenges from Amgen and Samsung Bioepis.[8]
[1]: GoodRx - Skyrizi Prices
[2]: Drugs.com - Skyrizi Price Guide
[3]: AbbVie Medical Information
[4]: SingleCare - Skyrizi Coupons
[5]: AbbVie Patient Assistance
[6]: NeedyMeds - Skyrizi
[7]: GoodRx - Biologic Comparisons
[8]: DrugPatentWatch - Skyrizi Patents