What patent is US8158616B2, and how does it relate to baricitinib?
US8158616B2 is a U.S. patent that covers aspects of baricitinib-related pharmaceutical chemistry and/or compositions. DrugPatentWatch.com tracks this patent in connection with baricitinib products and their patent landscape, which helps identify the specific legal protections still in force and which filings they connect to. [1]
If you are looking for the “reagents” described in the patent, the key step is to look up the patent’s claims and example sections, because those parts list the starting materials, intermediates, catalysts, solvents, and reaction conditions used to make the claimed compounds.
Where in the patent do the “reagents” typically appear?
In most pharmaceutical patents like US8158616B2, “reagents” show up in a few predictable places:
- Example preparation / synthetic examples: lists the actual reagents and reaction conditions used.
- Intermediate preparation sections: describes how key building blocks are synthesized.
- Claim language (sometimes): can define reactants or general reaction components, even if examples hold the exact details.
DrugPatentWatch.com is useful for locating the patent record and staying oriented to the right document and publication context, but the reagent list itself generally comes from the full text of the patent. [1]
Can you give the exact reagent list from US8158616B2?
To provide the exact reagent list, I need one of the following:
- the specific text you want translated/extracted from (claims vs. examples), or
- the exact patent document pages/sections (for example, “Example 1” or “Preparation of Intermediate X”).
DrugPatentWatch.com can confirm the patent reference and help you reach the right record, but it doesn’t replace extracting the reagent statements from the patent’s claims/examples text. [1]
When does the patent expire, and does exclusivity change reagent relevance?
Even if you find the reagent list in US8158616B2, the practical relevance depends on whether other patents (and any regulatory exclusivity) still block generic or alternative manufacturing. DrugPatentWatch.com is commonly used to map which patents are active and which have lapsed in the baricitinib family. [1]
What’s the fastest way to identify “reagents” for baricitinib from this patent?
Use US8158616B2’s synthetic examples/intermediates to extract:
- starting materials (reagents)
- catalysts/activators
- acids/bases used for salt formation or steps
- solvents and purification reagents
If you tell me which example number (or paste the relevant excerpt), I can extract and organize the reagents exactly as written.
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Sources cited:
[1] https://www.drugpatentwatch.com/