What is the usual Nuedexta (dextromethorphan/quinidine) dosage?
Nuedexta dosage is based on starting dose then increasing after the first week:
- Day 1–7: 1 capsule (20 mg/10 mg) by mouth once daily.
- Day 8 onward: 1 capsule (20 mg/10 mg) by mouth twice daily.
Take Nuedexta with or without food.
What if a dose is missed?
If you miss a dose, take it when you remember unless it is close to the next scheduled dose. Do not take two doses at once.
Can Nuedexta be used in liver or kidney problems?
Dose adjustments are important in people with organ impairment. Nuedexta should be used cautiously (and in some cases avoided) in people with significant liver disease. If you have liver or kidney issues, dosing should be confirmed with the prescribing clinician.
Who should not take Nuedexta (dosing safety issues)?
Nuedexta dosing can be affected by drug interactions and safety risks. It is especially important to review other medicines that can raise quinidine-related risk (for example, drugs that affect heart rhythm or are metabolized through pathways that quinidine can inhibit). Your prescriber should check your medication list before dosing.
Does Nuedexta dosing differ for people on interacting medications?
Yes. Because quinidine is part of Nuedexta, certain medicines may require avoiding Nuedexta or adjusting the plan. If you’re taking antidepressants, antipsychotics, certain antibiotics/antifungals, or other QT-prolonging drugs, ask your clinician or pharmacist whether any changes are needed to stay within safe dosing.
How soon do patients reach the full dose?
Patients typically reach the full target dosing of one capsule twice daily on Day 8.
Sources
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