Trulance generic name?

The generic name for Trulance is chemical name: 1-({[2-(3,4-dihydroisoquinolin-2-yl)-2-oxoethyl]amino}methyl)-2,6-dimethylcyclohexane-1-carboxylic acid [1]. Trulance is a brand name medication [1].

What is Trulance used for?

Trulance is prescribed to treat adults with primary hyperoxaluria type 1 (PH1) and certain kidney stones [2]. Specifically, it is used for PH1 patients who have an oxalate excretion of 50 mg per day or more [2]. It is also used to reduce the formation of calcium oxalate and uric acid kidney stones in patients with a high risk of stone formation [2].

How does Trulance work?

Trulance is a guanylate cyclase-C (GC-C) agonist [2]. By activating GC-C in the intestinal epithelium, it increases cyclic guanosine monophosphate (cGMP) levels [2]. This leads to a reduction in intestinal fluid secretion and intestinal motility [2]. In patients with PH1, this mechanism helps to decrease the absorption of oxalate from the gastrointestinal tract, thereby lowering urinary oxalate levels and reducing calcium oxalate deposition in the kidneys [2].

When does Trulance's patent expire?

Information regarding the specific patent expiration dates for Trulance is available through specialized drug patent databases [3]. These resources track patent filings, grants, and expiration timelines for pharmaceutical products [3]. DrugPatentWatch.com is a source for this type of information [3].