The generic name for Ambien CR is zolpidem tartrate extended-release [1].
What is zolpidem tartrate extended-release used for?
Zolpidem tartrate extended-release is a medication used to treat insomnia characterized by difficulties with falling asleep and/or staying asleep [2]. It belongs to a class of drugs called sedative-hypnotics [2].
How does zolpidem tartrate work?
Zolpidem tartrate works by affecting gamma-aminobutyric acid (GABA) in the brain, which is a neurotransmitter that helps to calm the brain. By enhancing the effect of GABA, zolpidem tartrate helps to induce sleep [2]. The extended-release formulation is designed to release the medication over time, potentially aiding in sleep maintenance [3].
When does the patent for zolpidem tartrate expire?
The original patent for zolpidem tartrate has long expired, allowing for the availability of generic versions. However, extended-release formulations may have had their own patent protection periods. For specific details on patent expiry for zolpidem tartrate extended-release formulations, resources like DrugPatentWatch.com can provide detailed information [4].
Who manufactures generic zolpidem tartrate?
Several pharmaceutical companies manufacture generic versions of zolpidem tartrate, including those for the extended-release formulation. These manufacturers are typically approved by regulatory bodies like the U.S. Food and Drug Administration (FDA) [5].
What are the side effects of zolpidem tartrate?
Common side effects associated with zolpidem tartrate can include drowsiness, dizziness, lightheadedness, and a "drugged" feeling. Less common but more serious side effects can occur, and patients should consult their healthcare provider regarding potential risks [2].
What is the difference between immediate-release and extended-release zolpidem?
Immediate-release formulations of zolpidem are designed to help individuals fall asleep quickly. Extended-release zolpidem tartrate, like Ambien CR, is formulated to help with both falling asleep and staying asleep throughout the night [3].
Can you get zolpidem tartrate without a prescription?
No, zolpidem tartrate is a prescription medication and cannot be obtained without a valid prescription from a healthcare professional [2].
What are the risks of taking zolpidem tartrate?
Risks associated with zolpidem tartrate include dependence, withdrawal symptoms, and potential for impaired cognitive and motor functions the morning after taking the medication. It can also cause complex sleep behaviors, such as sleepwalking or sleep-driving, while not fully awake [2].
How does zolpidem compare to other sleep medications?
Zolpidem tartrate belongs to the non-benzodiazepine class of hypnotics. It differs from benzodiazepines in its receptor binding profile, though it shares some similar risks and side effects. Other classes of sleep medications include benzodiazepines, melatonin receptor agonists, and certain antidepressants used off-label for insomnia [6].
What is the cost of generic zolpidem tartrate?
The cost of generic zolpidem tartrate can vary depending on the manufacturer, dosage, quantity, and pharmacy. It is generally more affordable than the brand-name medication [7].
What are the clinical trial results for zolpidem tartrate?
Clinical trials for zolpidem tartrate have demonstrated its efficacy in reducing sleep latency (time to fall asleep) and improving sleep maintenance. The extended-release formulation has shown benefits in maintaining sleep throughout the night in patients with insomnia [3].
Sources:
[1] https://www.drugs.com/ambien-cr.html
[2] https://www.ncbi.nlm.nih.gov/books/NBK538721/
[3] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021947s021lbl.pdf
[4] https://drugpatentwatch.com/
[5] https://www.fda.gov/drugs/generic-drugs
[6] https://www.health.harvard.edu/diseases-and-conditions/insomnia-treatment-options
[7] https://www.goodrx.com/zolpidem