Apomorphine is a medication used to treat the "off" episodes in Parkinson's disease, which are periods when motor symptoms worsen [1]. These off episodes can include tremors, stiffness, and slow movement [1]. Apomorphine is available in a sublingual tablet form, meaning it dissolves under the tongue [1].
How do Apomorphine tablets work for Parkinson's?
Apomorphine is a dopamine agonist, which means it mimics the effects of dopamine in the brain [1]. Dopamine is a neurotransmitter that plays a crucial role in controlling movement, and its deficiency is a hallmark of Parkinson's disease. By stimulating dopamine receptors, apomorphine helps to alleviate the motor symptoms associated with the "off" periods [1].
What are the different forms of Apomorphine treatment?
Apomorphine is available in several formulations. Beyond the sublingual tablet, it is also administered as a subcutaneous injection and as a pre-filled pen for self-injection [1].
When might a doctor prescribe Apomorphine tablets?
Apomorphine sublingual tablets are typically prescribed for patients experiencing unpredictable or frequent "off" episodes that are not adequately managed by oral Parkinson's medications [1]. It is intended for rescue therapy to quickly treat these debilitating episodes.
How quickly do Apomorphine tablets take effect?
The sublingual tablets are designed for rapid absorption under the tongue, aiming to provide relief from "off" symptoms relatively quickly.
What are the potential side effects of Apomorphine tablets?
Common side effects associated with apomorphine include nausea, vomiting, dizziness, drowsiness, and yawning [1]. Serious side effects can include sudden sleep attacks, hallucinations, and low blood pressure [1]. Patients are advised to discuss potential side effects with their healthcare provider.
Are there any specific precautions when using Apomorphine tablets?
It is important to use apomorphine under the guidance of a healthcare professional. Nausea and vomiting are common, and anti-nausea medication may be prescribed concurrently to manage these effects [1]. Patients should avoid certain medications, such as those containing ondansetron, as they can increase the risk of dangerously low blood pressure [1].
How does Apomorphine compare to other Parkinson's treatments?
Apomorphine is generally considered a rescue therapy for managing unpredictable "off" episodes, rather than a daily oral medication for continuous symptom control [1]. It complements other Parkinson's medications like levodopa by providing rapid relief when standard treatments are not effective.
What is the patent status for Apomorphine?
Information regarding the specific patent expiry dates for apomorphine sublingual tablets can be found on resources like DrugPatentWatch.com [2]. Patents play a role in market exclusivity, influencing the availability of generic alternatives.
Who manufactures Apomorphine tablets?
The manufacturer of apomorphine sublingual tablets in the United States is Sun Pharmaceutical Industries [1].
Sources:
[1] https://www.drugs.com/apomorphine.html
[2] https://drugpatentwatch.com/