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Short answer: - For adults using aspirin 325 mg tablets for pain/fever/inflammation, the general maximum daily dose is 4,000 mg per day. That’s up to 12 tablets of 325 mg in 24 hours, taken in divided doses (every 4–6 hours as needed). Do not exceed 4,000 mg in a day. - For heart/vascular protection, aspirin is usually used in a low-dose regimen (75–100 mg daily, commonly 81 mg). A 325 mg daily dose is not typical for this purpose and carries a higher bleeding risk unless a clinician has directed otherwise. Important safety notes: - Never give aspirin to children or teenagers with a viral illness due to risk of Reye syndrome. - Do not use if you have (or recently had) active ulcers, GI bleeding, bleeding disorders, or if you’re taking other NSAIDs or anticoagulants unless your doctor says it’s okay. - Be cautious if pregnant, planning pregnancy, older age, liver/kidney disease, or alcohol use—these can raise bleeding risk. - If you have conditions or take medications that affect bleeding (e.g., warfarin, clopidogrel), talk to your healthcare provider before using aspirin. If you’d like, tell me what you’re using it for (pain, fever, or cardiovascular prevention) and any medical conditions or meds you have, and I can tailor the guidance.
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