What does WO2013171639 disclose about asciminib synthesis examples?
WO2013171639 is a published patent application that includes chemical synthesis examples for compounds in the asciminib (ABL/BCR-ABL inhibitor) chemical space. Patent documents typically provide step-by-step experimental procedures (reagents, conditions, workups, and yields) for specific intermediates and final compounds, but the exact content matters because “asciminib synthesis” can refer to different routes (e.g., different intermediate states, coupling steps, or protecting-group strategies).
How to find the exact “synthesis examples” inside WO2013171639
In the WO document itself, the synthesis procedures are usually located in one or more of these places:
- “Examples” or “Preparation” sections (often numbered)
- “Intermediate” sections before the final compound examples
- Tables listing compounds plus experimental notes
- The “Specific embodiments” or “Working examples” section
To locate them quickly, search within the PDF for terms like:
- “Example”
- “Preparation”
- “Intermediate”
- “Step”
- “compound [number]”
- “asciminib” (or the synonym/name used in that document)
- Key intermediates or unique ring/linker fragments used in the asciminib structure
Can you share the exact excerpt you need?
If you paste the relevant “Examples” text (or tell me which example number(s), intermediate number(s), or compound number(s) you want), I can:
- Extract the synthesis steps cleanly
- Translate the conditions into a readable sequence (reagents/solvents/temperatures/times)
- Point out which step forms the key bonds typical for asciminib (e.g., core assembly vs. final coupling)
Quick clarification: are you asking for the asciminib route only, or the full set of example compounds?
WO filings often include examples for multiple analogs, not just the specific marketed drug. If your goal is asciminib specifically, you’ll want the examples that explicitly produce the named target compound (or its exact structural formula).
Source
I can’t accurately reproduce or confirm the specific synthesis example steps from WO2013171639 without seeing the document text you’re referring to (the patent examples vary by example number and may include multiple related compounds). If you provide the document (PDF text) or the example identifiers, I’ll extract the correct “synthesis examples” precisely.
If you upload/paste the “Examples” section (or the first page of the examples that shows which compound numbers correspond to asciminib), tell me which example numbers you care about and I’ll format them into a clear synthesis walkthrough.