Soliqua 100/33 is a prescription fixed-dose injectable for adults with type 2 diabetes. It combines insulin glargine (100 units/mL) with lixisenatide (33 mcg/mL) in one daily pen.
Key points:
- What it is: A once-daily subcutaneous injection that provides both basal insulin and a GLP-1 receptor agonist.
- Indication: Used to improve glycemic control in adults with type 2 diabetes when a regimen of basal insulin plus a GLP-1 receptor agonist is appropriate (often when basal insulin alone isn’t enough).
- Dose form: Each Soliqua 100/33 dose contains 100 units/mL insulin glargine and 33 mcg/mL lixisenatide.
Typical starting and titration (will be personalized by your clinician):
- Starting dose: 15 units once daily, injected before the first meal of the day.
- Titration: Increase by 15 units once weekly based on fasting glucose, up to a maximum of 60 units per day.
- Important: The amount of lixisenatide increases with the dose of Soliqua, since it’s a fixed combination.
How to use:
- Administer once daily, before the first meal of the day (preferably the same meal each day).
- Do not mix Soliqua with other insulins or GLP-1 receptor agonists in the same syringe.
- Rotate injection sites (abdomen, thigh, or upper arm) to reduce the chance of site reactions.
Safety and precautions:
- Contraindications: History of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2); personal or family history of MTC; known hypersensitivity to lixisenatide, insulin glargine, or any component of the formulation.
- Pancreatitis risk: GLP-1 receptor agonists have been associated with pancreatitis; monitor for persistent severe abdominal pain.
- Hypoglycemia: The combination can cause low blood sugar, especially if you miss meals, exercise more than usual, or take other glucose-lowering drugs (like sulfonylureas or other insulins). Adjustments to other meds may be needed.
- Pregnancy/lactation: Not recommended during pregnancy; discuss alternatives if planning pregnancy.
- Kidney or liver considerations: Use with caution as dosing may need adjustment; tell your doctor about kidney or liver problems.
- Other cautions: Watch for signs of thyroid problems (e.g., lump in the neck, trouble swallowing, hoarseness), gallbladder issues, or severe allergic reactions.
Storage:
- Unopened pens: refrigerate until first use.
- In-use pens: follow the product label for how long you can store at room temperature after first use and when to discard.
Cost and access:
- Soliqua is a prescription medicine; your prescriber can discuss whether it’s right for you, and your pharmacist can talk about coverage, coupons, or patient-assistance programs.
If you’d like, I can tailor this to your situation—e.g., what your current meds are, your A1c goal, and any health conditions—so I can help you prepare questions for your clinician or pharmacist. Do you want a quick checklist of questions to bring to your appointment, or more details on dosing and administration?