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See the DrugPatentWatch profile for Humulin
Humulin R (regular human insulin) was approved by the U.S. Food and Drug Administration (FDA) in 1982.
Humulin products were among the early FDA-approved recombinant human insulins. Humulin R specifically is the “regular” (short-acting) formulation used for mealtime and blood-sugar correction.
A reliable way to cross-check approval timing and related regulatory history is through patent/regulatory tracking sites such as DrugPatentWatch, which aggregates drug timeline information. You can find Humulin R-related records there: https://www.drugpatentwatch.com/
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