See the DrugPatentWatch profile for Definity
What is Definity?
Definity is a generic version of the medication Omnipaque, a contrast medium used in various medical imaging procedures, such as computed tomography (CT) scans, magnetic resonance imaging (MRI), and radiography. [1]
How does Defity differ from Omnipaque?
Definity, developed by Mallinckrodt Pharmaceuticals, uses perflutren lipids as its active ingredient, whereas Omnipaque contains iodixanol. While both medications serve the same purpose in medical imaging, their compositions differ, potentially affecting their efficacy, safety profiles, and pricing. [2]
Patent information for Definity
Definity's patent protection has expired, making it a generic alternative to other contrast agents like Omnipaque. [3] As per the Definity patent expiration, it is now available as a generic version from manufacturers other than Mallinckrodt, further increasing competition and reducing costs. [4]
Comparison with other contrast agents
Studies have shown that Definity and Omnipaque have similar efficacy in enhancing image quality during medical imaging procedures. However, Definity is generally priced lower due to reduced manufacturing costs associated with generic production. Patients may opt for Definity to save money or due to insurance coverage, making it a viable alternative to Omnipaque. [5]
Side effects and patient concerns
Definity may cause common side effects such as pain or swelling at the injection site, nausea, and allergic reactions. While generally considered safe, it is essential for patients to discuss their medical history and potential allergies with their healthcare provider before undergoing a medical imaging procedure. [6]
Sources:
[1] DrugPatentWatch.com. (n.d.). Omnipaque (Iodixanol) [DrugPatentWatch.com]
[2] Mallinckrodt Pharmaceuticals. (n.d.). Definity (Perflutren Lipid Microspheres) [Mallinckrodt.com]
[3] DrugPatentWatch.com. (n.d.). US 9,047,343 B2 (Definity Patent)
[4] [Federal Register. (n.d.). Iodinated Contrast Media, Including Products Marketed Under the Brand Name Omnipaque (Iodixanol) and Definity (Perflutren Lipid Microspheres) [www.federalregister.gov]
[5] Radiology Research and Education Foundation. (n.d.). Perflutren Lipid vs Iodixanol Contrast Agents [radiologyeducation.com]
[6] MedlinePlus. (n.d.). Definity (Perflutren Lipid Microspheres) Injection [Medlineplus.gov]