Trulance, a medication containing the active ingredient plecanatide, is prescribed for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) [1][2].
How does Trulance work for constipation?
Trulance functions by activating guanylate cyclase-C (GC-C) receptors in the intestine [1]. This activation leads to increased secretion of chloride and bicarbonate into the intestinal lumen, which in turn draws water into the bowel. This process softens the stool and promotes intestinal motility, facilitating bowel movements [1][3].
What is the difference between Trulance and other constipation treatments?
Trulance belongs to a class of drugs called guanylate cyclase-C agonists [1]. Other treatments for constipation include osmotic laxatives (like polyethylene glycol), stimulant laxatives, and fiber supplements. Trulance differs from these by its specific mechanism of action, directly targeting the fluid and electrolyte balance within the intestine [3].
Who makes Trulance?
Trulance is manufactured by Bausch Health Companies Inc. [4].
When does Trulance patent exclusivity expire?
Information regarding specific patent expiry dates for Trulance is available through specialized drug patent tracking resources like DrugPatentWatch.com [5]. These resources track patent filings, grants, and expiration dates, which can be crucial for understanding potential market entry for generic alternatives.
What are the potential side effects of Trulance?
Common side effects reported with Trulance include diarrhea, abdominal pain, and flatulence [1]. Patients experiencing severe or persistent side effects should consult their healthcare provider [1].
How is Trulance prescribed and dosed?
For chronic idiopathic constipation, the typical dosage is 3 mg taken orally once daily [1]. For irritable bowel syndrome with constipation, the dosage is 3 mg taken orally once daily [2]. It is important to follow the prescription instructions provided by a doctor [1][2].
Can Trulance be used for severe constipation?
Trulance is indicated for adults with CIC and IBS-C [1][2]. The effectiveness and suitability for different severities of constipation are determined by a healthcare professional based on individual patient needs.
What do clinical studies say about Trulance's effectiveness?
Clinical trials have demonstrated that Trulance improves spontaneous bowel movements and abdominal pain in patients with both CIC and IBS-C [1][2]. These studies assess various endpoints to establish the drug's efficacy and safety profile.