How long does Humira last unrefrigerated?
Humira (adalimumab) remains stable at room temperature (up to 25°C or 77°F) for up to 21 days, or until its expiration date, whichever comes first. Manufacturers recommend refrigeration at 2–8°C (36–46°F) for long-term storage, but brief room-temperature exposure doesn't ruin it. Discard if left out longer than 21 days total across multiple exposures.
What if it's accidentally left out overnight or during travel?
A single incident of 24–72 hours at room temp is generally fine if total unrefrigerated time stays under 21 days and the prefilled syringe or pen looks normal (no discoloration, particles, or damage). For air travel or power outages, use a cooler pack—Humira tolerates up to 30 minutes at higher temps like checked luggage heat.
Official storage rules from the label
Keep in original carton to protect from light. Do not freeze; if frozen, discard. After first use, store the pen upright at room temp for up to 21 days or refrigerate. Full prescribing info stresses monitoring total room-temp time cumulatively.[1]
Patient tips for avoiding waste
Track unrefrigerated days with a log or app. Pharmacies often provide travel kits. If in doubt post-exposure, contact AbbVie or your pharmacist—most cases under 21 days are usable, but they err on safe replacement.
[1] Humira Prescribing Information, AbbVie, https://www.rxabbvie.com/pdf/humira.pdf
[2] FDA Label for Adalimumab, https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/125057s423lbl.pdf